3 lbs is a drama that aired on CBS from November 14 to 28, 2006, replacing the cancelled series Smith. The show itself was then canceled three weeks later due to poor ratings. The title refers to the fact that the average human brain weighs approximately three pounds. The show follows the medical careers of prominent brain surgeon Doctor Douglas Hanson and his protégé, Jonathan Seger.

The show was promoted as, "The next great medical drama." The theme song is "Calling All Angels" by Train. Eight episodes were made, and the five episodes that did not originally air in the United States are available on Amazon Unbox.

The program filmed in New York City at the request of Tucci, who didn't want to be away from home to make the series.

When the pilot was originally filmed Dylan McDermott played Dr. Doug Hanson, and Reiko Aylesworth played Dr. Adrienne Holland.