The Sisters Brothers is a 2018 Western film directed by Jacques Audiard from a screenplay he co-wrote with Thomas Bidegain, based on the novel of the same name by Patrick deWitt. An American and French co-production, it is Audiard's first English-language work. The film stars John C. Reilly and Joaquin Phoenix as the notorious assassin brothers Eli and Charlie Sisters, and follows the two brothers as they chase after two men who have banded together to search for gold.