From an ominous Lecturer, a small 1930s middle American community learns of the Harper Affair, in which young Jimmy Harper finds his life of promise turn into a life of debauchery and murder thanks to the new drug menace marijuana. Along the way, he receives help from his girlfriend Mary and Jesus Himself, but always finds himself in the arms of the Reefer Man and the rest of the denizens of the Reefer Den.
Reefer Madness is a 1938/1939 American exploitation film about drugs, revolving around the melodramatic events that ensue when high school students are lured by pushers to try marijuana – upon trying it, they become addicted, eventually leading them to become involved in various crimes such as a hit and run accident, manslaughter, murder, conspiracy to murder and attempted rape. While all this is happening, they suffer hallucinations, descend into insanity, associate with organized crime and commit suicide. The film was directed by Louis J. Gasnier and featured a cast of mainly little-known actors.