Portland, Oregon, 1971. Bob Hughes is the charismatic leader of a peculiar quartet, formed by his wife, Dianne, and another couple, Rick and Nadine, who skillfully steal from drugstores and hospital medicine cabinets in order to appease their insatiable need for drugs. But neither fun nor luck last forever.
Drugstore Cowboy is a 1989 American crime drama film directed by the American filmmaker Gus Van Sant. Written by Van Sant and Daniel Yost and based on an autobiographical novel by James Fogle, the film stars Matt Dillon, Kelly Lynch, Heather Graham and William S. Burroughs. It was Van Sant's second film as director, following his 1988 debut Mala Noche.